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Wellcome Heart for Infectious Diseases Research in Africa (CIDRI-Africa)

Selected publications  |  Contact details  |  Grouping members  |  Collaborations

Senior Group Leader at The Francis Crick Found, London; and Wellcome Senior Fellow in Clinical Scientific discipline at Imperial College London [both posts seconded to the University of Cape Town]; Director, Centre for Infectious Diseases Research in Africa (CIDRI-Africa); Group leader and Manager, Crick African Network; and Member, Found of Communicable diseases and Molecular Medicine; Department of Medicine, Faculty of Health Sciences, University of Cape Town

Robert J. Wilkinson'southward interests are focused on clinical and immunological aspects of tuberculosis, particularly in the context of HIV-i infection.

HIV and TB are the most pressing public health problems in Africa: in South Africa, many hundreds of people still die prematurely per twenty-four hours considering of HIV, many due to co-existent TB. The epidemiology and clinical features of HIV associated TB are well researched, but few studies have addressed in detail the cellular mechanisms. His research programme derives its research questions from the clinical care of tuberculosis (TB) and HIV-TB co-infected persons in Southward Africa and London. Through clinically-based studies, they aim to improve knowledge of pathogenesis and thereby ameliorate prevention and handling. Projects underway now include the post-obit:

How can tuberculosis infection in HIV infected people be more effectively prevented?

By what immune mechanisms exercise preventive therapies decrease susceptibility to TB?

What is the cause and all-time management of the HIV-Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome? This project is led by Professor Graeme Meintjes, Professor and Infectious Diseases Physician, CIDRI-Africa, UCT.

What is the pathogenesis of tuberculous pericarditis?

How does HIV infection influence the immune responses to Mycobacterium tuberculosis in the lung?

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Selected publications:

Stucki, D., Brites, D., Jeljeli, Fifty., Coscolla, G., Liu, Q., Trauner, A., Fenner, L., Rutaihwa, 50., Borrell, S., Luo, T., Gao, Q., Kato-Maeda, M., Ballif, K., Egger, Thou., Macedo, R., Mardassi, H., Moreno, M., Vilanova, G.T., Fyfe, J., Globan, Chiliad., Thomas, J., Jamieson, F., Guthrie, J.50., Asante-Poku, A., Yeboah-Manu, D., Wampande, Due east., Ssengooba, W., Joloba, M., Smash, West.H., Basu, I., Bower, J., Saraiva, M., Vasconcellos, Southward.E.Yard., Suffys, P., Koch, A., Wilkinson, R., Gail-Bekker, L., Malla, B., Ley, S.D., Beck, H.-P., De Jong, B.C., Toit, K., Sanchez-Padilla, E., Bonnet, M., Gil-Brusola, A., Frank, Yard., Penlap Beng, Five.N., Eisenach, K., Alani, I., Ndung'U, P.Westward., Revathi, G., Gehre, F., Akter, South., Ntoumi, F., Stewart-Isherwood, L., Ntinginya, N.Due east., Rachow, A., Hoelscher, M., Cirillo, D.M., Skenders, Yard., Hoffner, S., Bakonyte, D., Stakenas, P., Diel, R., Crudu, V., Moldovan, O., Al-Hajoj, S., Otero, Fifty., Barletta, F., Carter, E.J., Diero, 50., Supply, P., Comas, I., Niemann, S., Gagneux, S. Mycobacterium tuberculosis lineage four comprises globally distributed and geographically restricted sublineages. Nature Genetics (2016) 48(12):1535-1543

Esmail, H., Lai, R.P., Lesosky, M., Wilkinson, K.A., Graham, C.M., Coussens, A.Thousand., Oni, T., Warwick, J.M., Said-Hartley, Q., Koegelenberg, C.F., Walzl, G., Flynn, J.L., Young, D.B., Barry, C.Due east., O'Garra, A., Wilkinson, R.J. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[ 18 F]fluoro-D-glucose positron emission and computed tomography. Nature Medicine (2016) 22(ten):1090-1093

Lai, RPJ; Meintjes, Grand; Wilkinson, KA; Graham, CM; Marais, Southward; Van der Plas, H; Deffur, A; Schutz, C; Bloom, C; Munagala, I; Anguiano, East; Goliath, R; Maartens, G; Banchereau, J; Chaussabel, D; O'Garra, A and Wilkinson, RJ. HIV-tuberculosis-associated allowed reconstitution inflammatory syndrome is characterized by Cost-similar receptor and inflammasome signalling. Nature Communications (2015) 6, 8451

Coussens, AK; Naude, CE; Goliath, R; Chaplin, G; Wilkinson, RJ and Jablonski, NG. High-dose vitamin D₃ reduces deficiency caused by low UVB exposure and limits HIV-one replication in urban Southern Africans. Proceedings of the National Academy of Sciences of the U.s. (2015) 112, 8052-8057

Anderson, Southward.T.B., Kaforou, M., Brent, A., Wright, V.J., Banwell, C.K., Chagaluka, G., Crampin, A.C., Dockrell, H.G., French, Northward., Hamilton, Grand.S., Hibberd, M.L., Kern, F., Langford, P.R., Ling, 50., Mlotha, R., Ottenhoff, T.H.M., Pienaar, Southward., Pillay, V., Scott, J.A.Yard, Twahir, H., Wilkinson, R.J., Coin, L.J., Heyderman, R.Southward., Levin, K., Eley, B. Diagnosis of childhood tuberculosis and host RNA expression in Africa. New England Journal of Medicine (2014) 370:1712-23

Martineau, A.R., Nhamoyebonde, Due south., Oni, T., Rangaka, M.X., Marais, S., Bangani, N., Tsekela, R., Bashe, L., de Azevedo, 5., Caldwell, J., Venton, T.R., Timms, P., Wilkinson, K.A., Wilkinson, R.J. Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Boondocks, Due south Africa. Proceedings of the National University of Sciences of the USA (2011) 108(47):19013-7

Berry, M.P.R., Graham, C.1000., McNab, F.W., Xu, Z., Bloch, S.J., Oni, T., Wilkinson, K.A., Banchereau, R., Skinner, J., Wilkinson, R.J., Quinn, C., Blankenship, D., Dhawan, R., Cush, J.J., Mejias, A., Ramilo, O., Kon, O.M., Pascual, 5., Banchereau, J., Chaussabel, D., and O'Garra, A. An Interferon-Inducible Neutrophil-Driven blood transcriptional signature in Human Tuberculosis. Nature (2010) 466: 973-977

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Contact details:

Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa)
Room 3.iii.05, Wolfson Pavilion
Institute of Infectious Disease and Molecular Medicine
Faculty of Health Sciences
Academy of Cape Boondocks
Observatory 7925
South Africa

Tel:  +27 21 406 6084
Fax: +27 21 406 6796

Electronic mail: robert.wilkinson@uct.ac.za
r.j.wilkinson@regal.ac.uk
robert.wilkinson@crick.ac.united kingdom

Alternate sites:https://www.crick.ac.united kingdom of great britain and northern ireland/research/a-z-researchers/researchers-v-y/robert-j-wilkinson/
www.cidri.uct.air-conditioning.za

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Group members:

Postgraduate students and postdoctoral fellows
Dr	Abhimanyu	Abhimanyu	Postdoctoral Fellow
Dr	Du Bruyn	Elsa	Doctoral student
Ms	Goliath	Rene	Masters educatee
Mr	Moseki	Moeketsi Raymond	Doctoral Student
Mr	Ndengane	Mthawelanga	Doctoral Pupil
Dr	Peton	Nashied	Postdoctoral Fellow
Dr	Seeger	Allison	Postdoctoral Fellow
Ms	Sibiya	Nomfundo	Doctoral educatee
Staff
Ms	Bam	Veronica	Research Nurse
Dr	Berkowitz	Natacha	Inquiry Medical Officer
Dr	Coussens	Anna	Senior Lecturer in Pathology
Dr	Du Bruyn	Elsa	Enquiry Medical Officer
Dr	Esmail	Hanif	Honorary Research Acquaintance, Great britain
Ms	Gobe	Nonceba	Clinical Research Worker
Ms	Goliath	Rene	Projects Co-ordinator
Ms	Jackson	Amanda	Information Systems Manager
Mrs	January	Vanessa	Lab Managing director
Mr	Kwaza	Bekekile	Clinical Research Worker
Mr	Lakay	Francisco	Senior Technical Officeholder
Ms	Letswalo	Kgothatso	Laboratory Technologist
Ms	Mashinyira	Antoneta	Data Control Co-ordinator
Ms	Mayiya	Mpume	Clinical Research Worker
Ms	McMaster	Meagan	Senior Information Capturer
Ms	Modolo	Khuthazwa	Research Nurse
Mrs	Morar	Tania	Part time Pharmacist
Mrs	Morey	Erika	Administrative Assistant
Dr	Mukasa	Sandra	Research Medical Officer
Ms	Ngcuka	Thembisa	Clinical Research Worker
Mrs	Omar-Davies	Nashreen	Radiographer
Dr	Rangaka	Molebogeng	Honorary Inquiry Associate, UK
Dr	Riou	Catherine	Senior Research Officer
Dr	Rockwood	Neesha	Honorary Research Associate, UK
Ms	Ruzive	Sheena	Laboratory Technologist
Mr	Sindelo	Sicelo	Research Nurse
Dr	Sossen	Bianca	Medical Research Officeholder
Ms	Thamae	Goitseone	Technical Officer
Dr	Thienemann	Friedrich	Senior Enquiry Medical Officer
Mrs	Van Wyhe	Pamela	Banana Nurse
Hon. A/Prof	Wilkinson	Katalin	Senior Scientist, Associate Professor
Ms	Wood	Kathryn	Heart Operations Manager
Mrs	Worship	Celeste	Data Capturer

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Collaborations:

Anne O'Garra, NIMR, UK

Clifton Earl Barry III, National Institutes of Health

Helen McShane, Oxford University

Alan Sher, National Institutes of Allergy and Infectious Diseases, United states

Jo-Anne Flynn, Academy of Pittsburgh, USA

Robert Southward Heyderman, University College London, UK

Gary Maartens, Division of Pharmacology and IDM, UCT

Bongani Mayosi, Department of Medicine and IDM, UCT

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Source: http://www.idm.uct.ac.za/Robert_Wilkinson

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